We are broadly interested in understanding how our experiences shape us. One of the most important functions of the brain is its ability to form memories, allowing us to adjust our behavior based on our past experiences. Because this flexibility is so central to the function of our brain, memory impairment is catastrophic to individuals, their families, and the health care system. Our research focuses on how brain plasticity works in normal conditions and how it is impaired in genetic disorders. Projects in the lab aim to address the following major questions:
How does learning reroute information flow in the brain? Learning generates neuronal and synaptic plasticity in the brain. We are imaging these changes in the brain in vivo with multiphoton microscopy, manipulating neuronal circuit activity with holographic optogenetics, and carrying out molecular manipulations to dissect the mechanisms of learning and memory at the molecular and circuit levels.
How do neuromodulatory circuits impact learning? Neuromodulatory circuits, such as those that release dopamine and serotonin, impact how we perceive the world and modulate learning & memory. We are studying how these circuits affect arousal, salience, and learning using imaging, optogenetics, and behavioral analysis.
How do genetic disorders affect cognitive function and behavior? Do alterations in metabolism play a role? Genetic disorders such as neurofibromatosis type 1 (NF1) affect multiple aspects of physiology, cognition, and behavior. NF1 increases the risk for other disorders such as attention-deficit/hyperactivity disorder and autism spectrum disorder. We are testing how genetic mutations underlying NF1 impact neuronal function, with an eye toward future interventions.
